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Biology 101 · Cell respiration
Why does the Krebs cycle need oxygen if it never uses O₂ directly?
Because it depends on NAD⁺ and FAD being recycled by the electron transport chain, and that chain only runs when oxygen is the final electron acceptor1. Without O₂, NADH builds up and the cycle stalls2.
1 · Campbell ch. 9, p. 1712 · Lecture 14 at 23:05
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